Mescaline exists as a naturally occurring drug derived from the peyote cactus plant. With an extensive history of use, mescaline has been used as a ritual part of ancient religious ceremonies as well as a recreational drug within today’s party scene.
Mescaline’s classification as a psychedelic hallucinogen places it within the Schedule I class of controlled substances, which all carry a potential for harm and no known medicinal benefits, according to Columbia University. Mescaline’s potential for harm stems from its effects on the brain over time. Likewise, mescaline tolerance becomes an ongoing risk, especially in cases of frequent, ongoing use.
While occasional drug use typically poses little risk for developing mescaline tolerance, it may be hard for some people to resist the drug for too long. When this is the case, the potential for mescaline tolerance effects stands to increase over time.
Mescaline’s Mechanism of Action
Chemically speaking, mescaline shares some similarities with ecstasy and 2C-B, both of which are “designer drugs” belonging to the phenethylamines class of psychedelic drugs. According to University of Maryland, phenethylamines closely resemble dopamine and norepinephrine, two essential brain neurotransmitter chemicals. These similarities greatly contribute to mescaline tolerance level changes.
Dopamine’s role in the brain works to regulate pain and pleasure sensations, which plays an integral role in learning and behavior. Norepinephrine acts as one of the body’s stress hormones and serves a vital role in responding to perceived threats and dangerous situations.
In effect, mescaline’s presence within the brain’s chemical system stimulates dopamine and norepinephrine chemical production. These interactions not only account for the hallucinogenic effects of the drug, but can offset the brain’s chemical balance over time.
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Mescaline Tolerance Effects
While not known to produce physical dependence, the brain does quickly develop a tolerance to mescaline with daily use. When tolerance levels increase, larger dosage amounts must be ingested to produce the same desired effects. With daily drug use, mescaline tolerance level increases can develop within three to six days’ time.
According to the Journal of Oxidative Medicine & Cellular Longevity, mescaline potency levels are considerably less than those of LSD and psilocybin, both of which carry a high brain tolerance potential. This means the rate of mescaline tolerance progresses much slower than that of these two drugs; however, mescaline does produce cross-tolerance effects that can carry over to similar type drugs.
While the potential for mescaline tolerance only exists when using the drug on a daily basis, the occasional use of this drug can still have a wearing effect on a person’s psychological makeup over time. Mescaline’s ability to produce exhilarating hallucinatory experiences offers an easy means for escaping daily life stressors.
When used for this purpose, the mind develops a dependence on mescaline’s effects in terms of using it as a way cope with everyday life. When this happens, the potential for more frequent drug use increases, which sets the stage for mescaline tolerance effects to unfold.
Whether used occasionally or on a daily basis, mescaline’s ability to alter the brain’s chemical system with each dose of the drug comes with a certain degree of risk. Once mescaline tolerance increases start to develop, it becomes increasingly difficult to maintain control over one’s drug-using behaviors over time.
If you suspect you or someone you know may be struggling with mescaline tolerance and need help finding treatment services that meet your needs, please feel free to call our toll-free helpline at 800-609-2774 to speak with one of our addictions specialists.